Insulin – like growth factor – binding protein 1 (iGFBP – 1) known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene. IGF – binding proteins (iGFBPs) is believed to be important in the regulation of fetal and neonatal growth. We previously reported that the profifiles of iGFBPs in fetal cord serum (FCS) were dependent on the growth/metabolic status of the fetus. It can be detected in cervical secretions of pregnant women with preterm uterine c ontractions, and whether their presence predicts an increased risk of preterm delivery. The abundance of insulin – like growth factor binding protein -1 at the maternal-fetal interface in severely preeclamptic pregnancies suggests that the binding protein may participate in the pathogenesis of the shallow placental invasion observed in this disorder. Low circulating insulin – like growth factor – I and elevated insulin-like growth factor binding protein – 1 levels may contri bute to restricted placental and therefore fetal growth.
The Insulin – like Growth Factor – binding Protein 1 (iGFBP – 1) Rapid Test is a rapid qualitative immunochromatographic test for the detection of phosphorylated iGFBP – 1 (insulin – like growth factor binding protein – 1) in cervical secretions during pregnancy
POSITIVE: * Two lines appear. One colored line should be in the control line region (C) and another apparent colored line should be in the test line region (T).
*NOTE: The intensity of the color in the test line region (T) will vary depending on the concentration of IGFBP-1 present in the specimen. Therefore, any shade of color in the test line region (T) should be considered positive.
NEGATIVE: One colored line appears in the control line region (C). No line appears in the test line region (T).
INVALID: Control line fails to appear. I nsuffiffifficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test with a new test. If the problem persists, discontinue using the test kit immediately and contact your local distributor.
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